A study was conducted in 2008 to evaluate the efficacy and tolerability of a mucoadhesive patch and compared with a pain relieving oral solution for the treatment of. Buccal patches for the delivery of atenolol using sodium alginate with various hydrophilic polymers like carbopol 934 p, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose in various proportions and combinations. New insight into the fabrication of smart mucoadhesive. Mucoadhesive polymers like hydroxypropylmethylcellulose k100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone k30 and carbopol934p were used.
Development and invitro evaluation of mucoadhesive buccal. The mucoadhesive buccal film of lisinopril were prepared by using various polymers like hpmc k4m, sodium cmc, pvp k30, eudragit rl 100, carbopol 934 by solvent casting method and evaluated for physical appearance, thickness, weight uniformity, folding endurance,percentage swelling index, percentage moisture content, drug diffusion studies and drug content estimation. Alginate particles as platform for drug delivery by the oral. The use of mucoadhesive polymers in buccal drug delivery has a greater application. Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. Mucoadhesive strength was performed in triplicate and. Buccal patches for the delivery of atenolol using sodium alginate with various hydrophilic polymers like carbopol 934 p, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose in various proportions and combinations were fabricated by solvent casting technique. Preparation of mucoadhesive patches for buccal administration. Mucoadhesive buccal patches and use of natural polymer in its. Sodium alginate and carbopol were introduced as a mucoadhesive layer and ethyl cellulose was the protective backing membrane. Invitro dissolution studies revealed that all the formulations exhibited nonfickian release kinetics. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Mucoadhesive patch were weighed individually x 0 and placed separately in 2% agar gel plates and incubated at 370c10c. The aim of the present study was to design mucoadhesive buccal film containing fluticasone that is aesthetically.
Buccal patch is a nondissolving thin matrix modified release dosage form composed of one or more. Alginate particles as platform for drug delivery by the. They can be prepared by two methods solvent casting method direct milling method 32020 31 department of pharmaceutical technology, lj institute of pharmacy, ahmedabad. The swelling index was proportional to chitosan and. The aim of the present study was to design mucoadhesive buccal film containing fluticasone that is aesthetically acceptable and could maintain local drug release. Formulation and evaluation of buccal patches of diclofenac. Carbopol 934, sodium alginate and hpmc k4m in combination. Experimental materials metoprolol succinate was obtained as a gift from aarti pharmaceuticals, india while sodium carboxymethylcellulose and chitosan were supplied by sigma pvt ltd, india. The drug containing layer was prepared by using pectin. Formulation, development and invitro evaluation of.
Bioadhesion, buccal delivery, microenvironmental ph, ondansetron hydrochloride. Department of pharmaceutical technology,41020 lj institute of pharmacy, ahmedabad 66 67. Chitosan, a derivative form of chitin, is a naturally. Attempts have been made to formulate various buccal mucoadhesive dosage forms, including tablets, films, patches, disks, and gels. The optimized patch exhibit an in vitro release of 82% through cellophane membrane and 70. The use of mucoadhesive polymers in buccal drug delivery has a. The present work was aimed with enhancement of oral bioavailability of sumatriptan succinate by sodium alginate based mucoadhesive buccal patches.
The formulations were characterised using texture analyser tensile and hardness. Research article design and evaluation of mucoadhesive buccal. Formulation and evaluation of buccal patches of diclofenac sodium shubhra pandey abstract. The patches were fabricated by solvent casting technique and were evaluated for invitro and exvivo drug release. Control of oral candidiasis using clotrimazole and. Carbopol 934sodium alginategelatin mucoadhesive ondansetron. Films can circumvent the difficulty of the relatively short.
Composite hpmc and sodium alginate based buccal formulations. In dentistry mucosal patches are being tried for various oral problems e. Design and development of buccal mucoadhesive drug delivery. Pdf formulation and evaluation of buccal patches for. Jun 09, 2010 the main goal of the present investigation efforts was to develop and evaluate new buccal patches comprising a drugcontaining mucoadhesive polymeric layer using polymers like sodium alginate, nacmc, hpmc, and cp 934 p in various combinations and proportions and a drugfree pvaaluminum foil backing membrane. The mucoadhesive buccal film of lisinopril were prepared by using various polymers like hpmc k4m, sodium cmc, pvp k30, eudragit rl 100, carbopol 934 by solvent casting method and evaluated for physical appearance, thickness, weight uniformity, folding endurance,percentage swelling index, percentage moisture content, drug diffusion studies and drug. Glycerine and dmso were used as plasticizer and penetration enhancer respectively. Various natural polymers which can be used in mucoadhesive buccal patches are chitosan, sodium alginate, tragacanth, gelatin and guar gum etc. Formulation and evaluation of mucoadhesive buccal films. In this study, mucoadhesive buccal patch of ramipril was prepared using poly vinyl alcohol pva, sodium alginate and hydroxy propyl methyl cellulose hpmc5 as mucoadhesive polymers and poly ethylene glycol peg 400 was used as plasticizer. A suitable buccal drug delivery system should possess good bioadhesive properties, so that it can be retained in the oral cavity for the desired duration.
A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive buccal patches and use of natural polymer in. Overview on buccal drug delivery systems pharmainfo. Ten formulations were prepared with varying concentrations of polymers using.
The patches were also evaluated for film weight uniformity, thickness, swelling index, surface ph, mucoadhesive strength. Abstract the aim of this article is to study the buccal patches. Buccal patches consists of two laminates, with an aqueous solution of the adhesive polymer being cast onto an impermeable backing sheet, which is then cut into the required oval shape. Apr 10, 20 give a brief account of mucoadhesive polymers for buccal delivery. Graph1 in vitro drug release profile terfenadine buccal patch conclusion buccal patches of terfenadine using polymers like sodium alginate, scmc and hpmc in various proportions showed satisfactory mucoadhesive characteristics. Ppt buccal drug delivery system powerpoint presentation. The backing membrane was prepared by using sodium alginate. Preparation of patches perindopril mucoadhesive buccal patches were prepared by solvent casting technique using chitosan, hpmck4m, sodium cmc, sodium alginate and polycarbophil as polymers. Design and in vitroin vivo evaluation of ultrathin. Fluticasone propionate is a synthetic corticosteroid drug distinguished by its potent antiinflammatory action with low systemic side effects in comparison to other corticosteroids making it a potential drug for local buccal delivery. Linagliptin buccal adhesive tablets formulation f1f7 were evaluated for their physicochemical properties that play a vital role in the drug release pattern.
To make the process more rational, coherent, efficient, and costeffective, the field of pharmaceutical materials science has emerged as the systematic study of the physicochemical properties and behavior of materials of pharmaceutical interest in relation to product. A novel mucosal adhesive film called zilactin consisting of an alcoholic solution of hpc and three organic acids. Formulation and evaluation of buccal patches for delivery of. Materials and methods materials sertraline hcl was obtained from glukempharmaceuticals, hyderabad, india. Formulation and evaluation of buccal patches for delivery. A clinical perspective on mucoadhesive buccal drug mafiadoc. Mucoadhesion is a process involving chemical interactions between mucin and polymers. New insight into the fabrication of smart mucoadhesive buccal. A combination of sodium alginate with carbopol934 and glycerol as plasticizer gives promising results.
Patches films liquid buccal adhesive dosage form viscous liquids mucoadhesive buccal films various mucoadhesive devices has been formulated like tablets,27 patches, 28 devices, strips,29 ointments,30 gels, 31 26 disks. Various mucoadhesive devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. Design and in vitro evaluation of buccal film of terfenadine. A clinical perspective on mucoadhesive buccal drug. Formulation and evaluation of mucoadhesive buccal film of. Boateng department of pharmaceutical chemical and environmental sciences, faculty of engineering and science, university of greenwich at medway, central avenue, chatham maritime, me4 4tb, kent, uk. Have designed and evaluated pharmacokinetics study of mucoadhesive buccal tablets of nicotine for smoking cessation using two mucoadhesive components hpmck4m sodium alginate has been reported. Mucoadhesive drug delivery system linkedin slideshare. The drug release from buccal films varied with respect to the polymer composition.
Composite hpmc and sodium alginate based buccal formulations for nicotine replacement therapy obinna c. The tests included goat buccal mucosa treated with buccal mucoadhesive films impregnated with the antifungal drug clotrimazole and quercetin individually and in combination. Design and development of buccal mucoadhesive drug. Curcumin mucoadhesive buccal propranolol mucoadhesive buccal resperidone mucoadhesive buccal salbutamol sulphate mucoadhesive buccal verapamil hcl, mucoadhesive buccal 2. Formulation and evaluation of buccal patches of diclofenac sodium. So right after i received the new 16 oz container of willpowder sodium alginate, i measured the volume in cubic centimeters by using a ruler and applied the equation for cylinder volume and measured about 647. The optimum patches exhibits an invitro drug release of 82% through cellophane membrane and 70. The use of mucoadhesive polymers in buccal drug delivery has gained a great attention. The purpose of this research was to study mucoadhesive buccal patches of granisetron hydrochloride using the bioadhesive polymers chitosan and sodium alginate. Buccal mucosa, buccal patch, diclofenac sodium, buccal delivery, sodium alginate, pectin abstract bilayerd films were prepared by solvent casting technique using different concentration of two polymers namely, sodium alginate and pectin. Matrix type the buccal patch designed in a matrix configuration contains drug, adhesive, and. Bilayerd films were prepared by solvent casting technique using different concentration of two polymers namely, sodium alginate and pectin. Attention towards mucoadhesive buccal drug delivery system.
Preparation and characterization of sodium alginate. A combination of sodium alginate with carbopol 934 and glycerol as plasticizer, gives promising results. Literature studies on preparation and evaluation of buccal. In vitro mucoadhesive potential of sodium alginate carbopol 934p microbeads this study was performed to check the mucoadhesive property of drug loaded microbeads so that it can release the drug locally where it may bound and retained in. Among the various transmucosal routes, buccal mucosa has excellent accessibility and relatively immobile mucosa, hence suitable for administration of retentive dosage form. Discuss the merits and demerits of mucoadhesive buccal drug delivery.
However, in most of the buccal patches the drug is dispersed within the polymeric matrix bushetti et al. Pravastatin sodium lowers plasma cholesterol levels in hypercholesterolemia subjects. Among all formulations, the maximum in vitro drug release was observed in the case of formulation f185%. Goat buccal mucosa along with culture only, was maintained as control.
Jun 06, 20 atenolol was used as a model drug to design oral controlled release mucoadhesive tablet by singh et al. Formulation and evaluation of nitrendipine buccal films. Materials and methods materials zidovudine was purchased from ysp sdn. The aim of this study was to design and optimize risperidone ris mucoadhesive buccal tablets for systemic delivery as an alternative route. In this design, saliva penetration into the patch and dissolution of the drug were low and the release of the drug was in a controlled manner 59. The swelling index was proportional to chitosan and sodium alginate content. Buccal patches films they are long, flat, thin thickness, transparent with high surface area. Buccal patches for the delivery of atenolol using sodium alginate with various hydrophilic polymers like carbopol 934 p, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose in. Bilaminatd patches composed of mixture of drug methotrexate and sodium alginate alone or in combination with sodium carboxy methylcellulose,polyvinylpyrrolidine and carbopol 934 and backing membrane ethyl cellulose. Various mucoadhesive dosage forms, including tablets, patches, disks, wafers, ointments and gels have recently been developed. Pharmaceutical research and development aims to design products with ensured safety, quality, and efficacy to treat disease.
However, buccal patch offer greater flexibility and comfort than the other devices. Sodium alginate hydroxyethyl cellulose hydroxypropyl methylcellulose chitosan gelatin pectin 15. To make the process more rational, coherent, efficient, and costeffective, the field of pharmaceutical materials science has emerged as the systematic study of the physicochemical properties and behavior of materials of pharmaceutical interest in relation. A clinical perspective on mucoadhesive buccal drug delivery. Formulation and evaluation of alginatebased mucoadhesive. Atenolol was used as a model drug to design oral controlled release mucoadhesive tablet by singh et al. Research article design and evaluation of mucoadhesive.
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